Reaction Details Report a problem with these data
Target
High affinity choline transporter 1
Ligand
BDBM87579
Substrate
n/a
Meas. Tech.
JHICC_CHT_Inh_3H uptake_CRC
IC50
446.683592±n/a nM
Citation
 PubChem, PC JHICC_CHT_Inh_3H uptake_CRC PubChem Bioassay (2012)[AID] 
Target
Name:
High affinity choline transporter 1
Synonyms:
CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1
Type:
PROTEIN
Mol. Mass.:
63194.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1464247
Residue:
580
Sequence:
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
  
Inhibitor
Name:
BDBM87579
Synonyms:
MLS001239889 | N-(4-{[(2,6-dimethyl-4-pyrimidinyl)amino]sulfonyl}phenyl)-2,3,4,5,6-pentafluorobenzamide | N-[4-[(2,6-dimethyl-4-pyrimidinyl)sulfamoyl]phenyl]-2,3,4,5,6-pentafluorobenzamide | N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2,3,4,5,6-pentafluoro-benzamide | N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2,3,4,5,6-pentafluorobenzamide | N-[4-[(2,6-dimethylpyrimidin-4-yl)sulfamoyl]phenyl]-2,3,4,5,6-pentakis(fluoranyl)benzamide | SMR000673289 | cid_1744440
Type:
Small organic molecule
Emp. Form.:
C19H13F5N4O3S
Mol. Mass.:
472.389
SMILES:
Cc1cc(NS(=O)(=O)c2ccc(NC(=O)c3c(F)c(F)c(F)c(F)c3F)cc2)nc(C)n1
Structure:
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