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Target
Polyadenylate-binding protein 1
Ligand
BDBM87598
Substrate
n/a
Meas. Tech.
Dose-response secondary confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay using Cy5 labeled peptide
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response secondary confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay using Cy5 labeled peptide PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87598
Synonyms:
(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-acetic acid 1-[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-propyl ester | 2-(3-keto-4H-1,4-benzothiazin-2-yl)acetic acid 1-(tetrahydrofurfurylcarbamoyl)propyl ester | 2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetic acid [1-oxo-1-(2-oxolanylmethylamino)butan-2-yl] ester | MLS000030352 | SMR000008054 | [1-oxidanylidene-1-(oxolan-2-ylmethylamino)butan-2-yl] 2-(3-oxidanylidene-4H-1,4-benzothiazin-2-yl)ethanoate | [1-oxo-1-(oxolan-2-ylmethylamino)butan-2-yl] 2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetate | cid_648790
Type:
Small organic molecule
Emp. Form.:
C19H24N2O5S
Mol. Mass.:
392.469
SMILES:
CCC(OC(=O)CC1Sc2ccccc2NC1=O)C(=O)NCC1CCCO1
Structure:
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