Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM34395
Substrate
n/a
Meas. Tech.
Dose-response secondary confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay using Cy5 labeled peptide
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response secondary confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay using Cy5 labeled peptide PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM34395
Synonyms:
4-amino-3-(2-methoxyphenyl)-2-sulfanylidene-1,3-thiazole-5-carboxamide | 4-amino-3-(2-methoxyphenyl)-2-sulfanylidene-5-thiazolecarboxamide | 4-amino-3-(2-methoxyphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxamide | 4-amino-3-(2-methoxyphenyl)-2-thioxo-4-thiazoline-5-carboxamide | 4-azanyl-3-(2-methoxyphenyl)-2-sulfanylidene-1,3-thiazole-5-carboxamide | MLS000043080 | SMR000019507 | cid_3243618
Type:
Small organic molecule
Emp. Form.:
C11H11N3O2S2
Mol. Mass.:
281.354
SMILES:
COc1ccccc1-n1c(N)c(sc1=S)C(N)=O |(3.08,-2.9,;4.41,-2.13,;5.75,-2.9,;5.75,-4.44,;7.08,-5.21,;8.41,-4.44,;8.41,-2.9,;7.08,-2.13,;7.08,-.59,;5.84,.32,;4.37,-.16,;6.31,1.78,;7.85,1.78,;8.33,.32,;9.79,-.16,;5.41,3.03,;6.03,4.44,;3.87,2.87,)|
Structure:
Search PDB for entries with ligand similarity: