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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM88920
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
11900±1820 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM88920
Synonyms:
MLS001003751 | N-[(E)-3-pyridinylmethylideneamino]-2-benzo[cd]indolamine | N-[(E)-pyridin-3-ylmethylideneamino]benzo[cd]indol-2-amine | SMR000347599 | benzo[cd]indol-2-yl-[(E)-3-pyridylmethyleneamino]amine | cid_6899631
Type:
Small organic molecule
Emp. Form.:
C17H12N4
Mol. Mass.:
272.304
SMILES:
N(N=Cc1cccnc1)C1=Nc2cccc3cccc1c23 |w:1.0,t:10|
Structure:
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