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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM60885
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
9050±800 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM60885
Synonyms:
(2E)-2-[(2Z)-2-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-2-[(2Z)-2-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-2-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-3-(4-methoxyphenyl)-2-[(2Z)-2-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | MLS001173609 | SMR000538663 | cid_24747637
Type:
Small organic molecule
Emp. Form.:
C23H18N2O4
Mol. Mass.:
386.4
SMILES:
COc1ccc(cc1)-n1c(C=Cc2ccc(O)c(O)c2)nc2ccccc2c1=O |w:10.10|
Structure:
Search PDB for entries with ligand similarity: