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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM89008
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
46200±35900 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
PSMD14 protein | PSDE_HUMAN | PSMD14 | POH1 | 26S Proteasome regulatory subunit Rpn11 (Rpn11)
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Human
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM89008
Synonyms:
2-(2-ethylphenoxy)-N-(2-methyl-4-pyrrolidin-1-ylphenyl)acetamide | 2-(2-ethylphenoxy)-N-(2-methyl-4-pyrrolidin-1-yl-phenyl)ethanamide | SMR001243458 | cid_4853066 | 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]acetamide | MLS002161030 | 2-(2-ethylphenoxy)-N-(2-methyl-4-pyrrolidino-phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C21H26N2O2
Mol. Mass.:
338.20
SMILES:
CCc1ccccc1OCC(=O)Nc1ccc(cc1C)N1CCCC1
Structure:
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