Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM60885
Substrate
n/a
Meas. Tech.
Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay
IC50
6490±1620 nM
Citation
 PubChem, PC Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain
Type:
Enzyme
Mol. Mass.:
70502.73
Organism:
Bos taurus (Bovine)
Description:
P00735
Residue:
625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
  
Inhibitor
Name:
BDBM60885
Synonyms:
(2E)-2-[(2Z)-2-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-2-[(2Z)-2-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-2-[(2Z)-2-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one | (2E)-3-(4-methoxyphenyl)-2-[(2Z)-2-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | MLS001173609 | SMR000538663 | cid_24747637
Type:
Small organic molecule
Emp. Form.:
C23H18N2O4
Mol. Mass.:
386.4
SMILES:
COc1ccc(cc1)-n1c(C=Cc2ccc(O)c(O)c2)nc2ccccc2c1=O |w:10.10|
Structure:
Search PDB for entries with ligand similarity: