Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM61285
Substrate
n/a
Meas. Tech.
Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay
IC50
4790±n/a nM
Citation
 PubChem, PC Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay PubChem Bioassay (2012)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM61285
Synonyms:
2-[2-[(N''E)-N''-[3-(2,4-dichlorobenzyl)oxy-4-methoxy-benzylidene]hydrazino]-4-keto-2-thiazolin-5-yl]acetic acid | 2-[2-[(N'E)-N'-[3-(2,4-dichlorobenzyl)oxy-4-methoxy-benzylidene]hydrazino]-4-keto-2-thiazolin-5-yl]acetic acid | 2-[2-[2-[[3-[(2,4-dichlorophenyl)methoxy]-4-methoxy-phenyl]methylidene]hydrazinyl]-4-oxidanylidene-1,3-thiazol-5-yl]ethanoic acid | 2-[2-[2-[[3-[(2,4-dichlorophenyl)methoxy]-4-methoxyphenyl]methylidene]hydrazinyl]-4-oxo-1,3-thiazol-5-yl]acetic acid | 2-[2-[2-[[3-[(2,4-dichlorophenyl)methoxy]-4-methoxyphenyl]methylidene]hydrazinyl]-4-oxo-5-thiazolyl]acetic acid | 2-[2-[N'-[3-(2,4-dichlorobenzyl)oxy-4-methoxy-benzylidene]hydrazino]-4-keto-2-thiazolin-5-yl]acetic acid | MLS000574282 | SMR000195873 | [2-({3-[(2,4-dichlorobenzyl)oxy]-4-methoxybenzylidene}hydrazono)-4-oxo-1,3-thiazolidin-5-yl]acetic acid | cid_2908089
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2N3O5S
Mol. Mass.:
482.337
SMILES:
COc1ccc(CN=Nc2nc(O)c(CC(O)=O)s2)cc1OCc1ccc(Cl)cc1Cl |w:8.8|
Structure:
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