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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89535
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89535
Synonyms:
4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-3H-thiazol-2-ylideneamine | 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2-amine;hydrochloride | 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-thiazolamine;hydrochloride | MLS000031847 | SMR000012139 | [4-(2,3-dihydro-1,4-benzodioxin-6-yl)thiazol-2-yl]amine;hydrochloride | cid_6603336
Type:
Small organic molecule
Emp. Form.:
C11H10N2O2S
Mol. Mass.:
234.274
SMILES:
Nc1nc(cs1)-c1ccc2OCCOc2c1
Structure:
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