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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM29629
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM29629
Synonyms:
1-(2-furanylmethyl)-3-(3-methylphenyl)sulfonyl-2-pyrrolo[3,2-b]quinoxalinamine | 1-(furan-2-ylmethyl)-3-(3-methylphenyl)sulfonyl-pyrrolo[3,2-b]quinoxalin-2-amine | 1-(furan-2-ylmethyl)-3-(3-methylphenyl)sulfonylpyrrolo[3,2-b]quinoxalin-2-amine | MLS000042130 | SMR000048006 | [1-(2-furfuryl)-3-(m-tolylsulfonyl)pyrrolo[3,2-b]quinoxalin-2-yl]amine | cid_666651
Type:
Small organic molecule
Emp. Form.:
C22H18N4O3S
Mol. Mass.:
418.468
SMILES:
Cc1cccc(c1)S(=O)(=O)c1c(N)n(Cc2ccco2)c2nc3ccccc3nc12
Structure:
Search PDB for entries with ligand similarity: