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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM77495
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM77495
Synonyms:
4-(m-anisoylamino)-2,3-dihydrothiophene-5-carboxylic acid methyl ester | 4-[[(3-methoxyphenyl)-oxomethyl]amino]-2,3-dihydrothiophene-5-carboxylic acid methyl ester | MLS000087766 | SMR000023986 | cid_3241864 | methyl 3-[(3-methoxybenzoyl)amino]-4,5-dihydrothiophene-2-carboxylate | methyl 4-[(3-methoxybenzoyl)amino]-2,3-dihydrothiophene-5-carboxylate | methyl 4-[(3-methoxyphenyl)carbonylamino]-2,3-dihydrothiophene-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H15NO4S
Mol. Mass.:
293.338
SMILES:
COC(=O)C1=C(CCS1)NC(=O)c1cccc(OC)c1 |t:4|
Structure:
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