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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM43901
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM43901
Synonyms:
2-[(4-fluorobenzyl)thio]-N-[2-(2-fluorophenoxy)ethyl]benzamide | N-[2-(2-fluoranylphenoxy)ethyl]-2-[(4-fluorophenyl)methylsulfanyl]benzamide | N-[2-(2-fluorophenoxy)ethyl]-2-[(4-fluorophenyl)methylsulfanyl]benzamide | N-[2-(2-fluorophenoxy)ethyl]-2-[(4-fluorophenyl)methylthio]benzamide | VU0269430-2-D15 | cid_573357
Type:
Small organic molecule
Emp. Form.:
C22H19F2NO2S
Mol. Mass.:
399.454
SMILES:
Fc1ccc(CSc2ccccc2C(=O)NCCOc2ccccc2F)cc1
Structure:
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