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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90219
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
6430±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90219
Synonyms:
(E,4Z)-N-(4-chlorophenyl)-2-cyano-4-(1,3,3-trimethyl-2-indolylidene)-2-butenamide | (E,4Z)-N-(4-chlorophenyl)-2-cyano-4-(1,3,3-trimethylindol-2-ylidene)but-2-enamide | (E,4Z)-N-(4-chlorophenyl)-2-cyano-4-(1,3,3-trimethylindolin-2-ylidene)but-2-enamide | MLS000402476 | SMR000263757 | cid_2345437
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O
Mol. Mass.:
377.867
SMILES:
CN1\C(=C/C=C(\C#N)C(=O)Nc2ccc(Cl)cc2)C(C)(C)c2ccccc12
Structure:
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