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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90230
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90230
Synonyms:
2-[3-[2-(1-cyclohexenyl)ethyl]-2-(2-ethoxyphenyl)imino-4-oxo-5-thiazolidinyl]-N-(2,4-dimethoxyphenyl)acetamide | 2-[3-[2-(cyclohexen-1-yl)ethyl]-2-(2-ethoxyphenyl)imino-4-oxidanylidene-1,3-thiazolidin-5-yl]-N-(2,4-dimethoxyphenyl)ethanamide | 2-[3-[2-(cyclohexen-1-yl)ethyl]-2-(2-ethoxyphenyl)imino-4-oxo-1,3-thiazolidin-5-yl]-N-(2,4-dimethoxyphenyl)acetamide | 2-[3-[2-(cyclohexen-1-yl)ethyl]-4-keto-2-o-phenetylimino-thiazolidin-5-yl]-N-(2,4-dimethoxyphenyl)acetamide | MLS000394918 | SMR000262167 | cid_3881168
Type:
Small organic molecule
Emp. Form.:
C29H35N3O5S
Mol. Mass.:
537.67
SMILES:
CCOc1ccccc1\N=C1/SC(CC(=O)Nc2ccc(OC)cc2OC)C(=O)N1CCC1=CCCCC1 |t:35|
Structure:
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