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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90231
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90231
Synonyms:
2,2-diphenyl-N-(tetrahydrofurfurylthiocarbamoyl)acetamide | MLS000704224 | N-(diphenylacetyl)-N'-(tetrahydro-2-furanylmethyl)thiourea | N-(oxolan-2-ylmethylcarbamothioyl)-2,2-diphenyl-ethanamide | N-(oxolan-2-ylmethylcarbamothioyl)-2,2-diphenylacetamide | N-[(2-oxolanylmethylamino)-sulfanylidenemethyl]-2,2-diphenylacetamide | SMR000228791 | cid_3994703
Type:
Small organic molecule
Emp. Form.:
C20H22N2O2S
Mol. Mass.:
354.466
SMILES:
O=C(NC(=S)NCC1CCCO1)C(c1ccccc1)c1ccccc1
Structure:
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