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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM57661
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM57661
Synonyms:
(2Z)-2-[3-methyl-4-oxidanylidene-6-phenyl-6-(trifluoromethyl)-1,3,5-thiadiazinan-2-ylidene]-2-(5-morpholin-4-yl-4-phenyl-1,2,4-triazol-3-yl)ethanenitrile | (2Z)-2-[3-methyl-4-oxo-6-phenyl-6-(trifluoromethyl)-1,3,5-thiadiazinan-2-ylidene]-2-(5-morpholin-4-yl-4-phenyl-1,2,4-triazol-3-yl)acetonitrile | (2Z)-2-[3-methyl-4-oxo-6-phenyl-6-(trifluoromethyl)-1,3,5-thiadiazinan-2-ylidene]-2-[5-(4-morpholinyl)-4-phenyl-1,2,4-triazol-3-yl]acetonitrile | (2Z)-2-[4-keto-3-methyl-6-phenyl-6-(trifluoromethyl)-1,3,5-thiadiazinan-2-ylidene]-2-(5-morpholino-4-phenyl-1,2,4-triazol-3-yl)acetonitrile | MLS000391958 | SMR000260991 | cid_6250439
Type:
Small organic molecule
Emp. Form.:
C25H22F3N7O2S
Mol. Mass.:
541.548
SMILES:
CN1C(=O)NC(SC1=C(C#N)c1nnc(N2CCOCC2)n1-c1ccccc1)(c1ccccc1)C(F)(F)F |w:7.6|
Structure:
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