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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM60556
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM60556
Synonyms:
2-(1-benzotriazolyl)acetic acid [2-[4-(dimethylamino)anilino]-2-oxoethyl] ester | 2-(benzotriazol-1-yl)acetic acid [2-[4-(dimethylamino)anilino]-2-keto-ethyl] ester | MLS000417566 | SMR000264490 | [2-[4-(dimethylamino)anilino]-2-oxoethyl] 2-(benzotriazol-1-yl)acetate | [2-[[4-(dimethylamino)phenyl]amino]-2-oxidanylidene-ethyl] 2-(benzotriazol-1-yl)ethanoate | cid_2554025
Type:
Small organic molecule
Emp. Form.:
C18H19N5O3
Mol. Mass.:
353.3752
SMILES:
CN(C)c1ccc(NC(=O)COC(=O)Cn2nnc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: