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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90237
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
4600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90237
Synonyms:
2-(4-benzoylphenoxy)-N-[4-(isopropylsulfamoyl)phenyl]propionamide | 2-(4-benzoylphenoxy)-N-[4-(propan-2-ylsulfamoyl)phenyl]propanamide | 2-[4-(phenylcarbonyl)phenoxy]-N-[4-(propan-2-ylsulfamoyl)phenyl]propanamide | MLS000416488 | SMR000243396 | cid_4881083
Type:
Small organic molecule
Emp. Form.:
C25H26N2O5S
Mol. Mass.:
466.549
SMILES:
CC(C)NS(=O)(=O)c1ccc(NC(=O)C(C)Oc2ccc(cc2)C(=O)c2ccccc2)cc1
Structure:
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