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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90239
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90239
Synonyms:
MLS000390055 | N-(5-methoxy-2-methyl-4-nitro-phenyl)-2-(1-phenylbenzimidazol-2-yl)sulfanyl-ethanamide | N-(5-methoxy-2-methyl-4-nitro-phenyl)-2-[(1-phenylbenzimidazol-2-yl)thio]acetamide | N-(5-methoxy-2-methyl-4-nitrophenyl)-2-(1-phenylbenzimidazol-2-yl)sulfanylacetamide | N-(5-methoxy-2-methyl-4-nitrophenyl)-2-[(1-phenyl-2-benzimidazolyl)thio]acetamide | SMR000259319 | cid_3615290
Type:
Small organic molecule
Emp. Form.:
C23H20N4O4S
Mol. Mass.:
448.494
SMILES:
COc1cc(NC(=O)CSc2nc3ccccc3n2-c2ccccc2)c(C)cc1[N+]([O-])=O
Structure:
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