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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90242
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90242
Synonyms:
2-[2-[4-(1-oxo-2,2-diphenylethyl)-1-piperazinyl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-(2,2-diphenylacetyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-(2,2-diphenylacetyl)piperazino]ethyl]benzo[de]isoquinoline-1,3-quinone | 2-[2-[4-(2,2-diphenylethanoyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione | MLS000374979 | SMR000254333 | cid_3338614
Type:
Small organic molecule
Emp. Form.:
C32H29N3O3
Mol. Mass.:
503.591
SMILES:
O=C(C(c1ccccc1)c1ccccc1)N1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1
Structure:
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