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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90243
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90243
Synonyms:
3-[(7-methoxy-4-methyl-quinolin-2-yl)sulfanylmethyl]-1,2,3-benzotriazin-4-one | 3-[(7-methoxy-4-methylquinolin-2-yl)sulfanylmethyl]-1,2,3-benzotriazin-4-one | 3-[[(7-methoxy-4-methyl-2-quinolinyl)thio]methyl]-1,2,3-benzotriazin-4-one | 3-[[(7-methoxy-4-methyl-2-quinolyl)thio]methyl]-1,2,3-benzotriazin-4-one | MLS000389912 | SMR000256186 | cid_2085879
Type:
Small organic molecule
Emp. Form.:
C19H16N4O2S
Mol. Mass.:
364.421
SMILES:
COc1ccc2c(C)cc(SCn3nnc4ccccc4c3=O)nc2c1
Structure:
Search PDB for entries with ligand similarity: