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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90244
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90244
Synonyms:
MLS000394963 | N-[3-(4-benzhydrylpiperazine-1-carbonyl)phenyl]-3,4-difluoro-benzenesulfonamide | N-[3-(4-benzhydrylpiperazine-1-carbonyl)phenyl]-3,4-difluorobenzenesulfonamide | N-[3-[4-(diphenylmethyl)piperazin-1-yl]carbonylphenyl]-3,4-bis(fluoranyl)benzenesulfonamide | N-[3-[[4-(diphenylmethyl)-1-piperazinyl]-oxomethyl]phenyl]-3,4-difluorobenzenesulfonamide | SMR000248392 | cid_4098333
Type:
Small organic molecule
Emp. Form.:
C30H27F2N3O3S
Mol. Mass.:
547.615
SMILES:
Fc1ccc(cc1F)S(=O)(=O)Nc1cccc(c1)C(=O)N1CCN(CC1)C(c1ccccc1)c1ccccc1
Structure:
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