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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90248
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90248
Synonyms:
3-(dimethylamino)benzoic acid [2-keto-2-[2-(phenylthio)anilino]ethyl] ester | 3-(dimethylamino)benzoic acid [2-oxo-2-[2-(phenylthio)anilino]ethyl] ester | MLS000334925 | SMR000249683 | [2-oxidanylidene-2-[(2-phenylsulfanylphenyl)amino]ethyl] 3-(dimethylamino)benzoate | [2-oxo-2-(2-phenylsulfanylanilino)ethyl] 3-(dimethylamino)benzoate | cid_2079073
Type:
Small organic molecule
Emp. Form.:
C23H22N2O3S
Mol. Mass.:
406.497
SMILES:
CN(C)c1cccc(c1)C(=O)OCC(=O)Nc1ccccc1Sc1ccccc1
Structure:
Search PDB for entries with ligand similarity: