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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90249
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90249
Synonyms:
2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid [2-(4-cyanoanilino)-2-keto-ethyl] ester | 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetic acid [2-(4-cyanoanilino)-2-oxoethyl] ester | MLS000334939 | SMR000249697 | [2-(4-cyanoanilino)-2-oxoethyl] 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetate | [2-[(4-cyanophenyl)amino]-2-oxidanylidene-ethyl] 2-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoate | cid_2078982
Type:
Small organic molecule
Emp. Form.:
C19H13ClN4O4S
Mol. Mass.:
428.849
SMILES:
Clc1ccc(cc1)-c1nnc(SCC(=O)OCC(=O)Nc2ccc(cc2)C#N)o1
Structure:
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