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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90251
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90251
Synonyms:
4-ethoxy-N-[3-(4-morpholin-4-ylanilino)quinoxalin-2-yl]benzenesulfonamide | 4-ethoxy-N-[3-(4-morpholinoanilino)quinoxalin-2-yl]benzenesulfonamide | 4-ethoxy-N-[3-[(4-morpholin-4-ylphenyl)amino]quinoxalin-2-yl]benzenesulfonamide | 4-ethoxy-N-[3-[4-(4-morpholinyl)anilino]-2-quinoxalinyl]benzenesulfonamide | MLS000394992 | SMR000248385 | US20230364057, Compound 130 | cid_2334042
Type:
Small organic molecule
Emp. Form.:
C26H27N5O4S
Mol. Mass.:
505.589
SMILES:
CCOc1ccc(cc1)S(=O)(=O)Nc1nc2ccccc2nc1Nc1ccc(cc1)N1CCOCC1
Structure:
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