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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90252
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90252
Synonyms:
4-(2-methylquinolin-8-yl)oxy-5-phenyl-thieno[2,3-d]pyrimidine | 4-(2-methylquinolin-8-yl)oxy-5-phenylthieno[2,3-d]pyrimidine | 4-[(2-methyl-8-quinolinyl)oxy]-5-phenylthieno[2,3-d]pyrimidine | 4-[(2-methyl-8-quinolyl)oxy]-5-phenyl-thieno[2,3-d]pyrimidine | MLS000416418 | SMR000264228 | cid_3843899
Type:
Small organic molecule
Emp. Form.:
C22H15N3OS
Mol. Mass.:
369.439
SMILES:
Cc1ccc2cccc(Oc3ncnc4scc(-c5ccccc5)c34)c2n1
Structure:
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