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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM64639
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM64639
Synonyms:
(E)-3-(5-chloranyl-3-methyl-1-phenyl-pyrazol-4-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one | (E)-3-(5-chloro-3-methyl-1-phenyl-4-pyrazolyl)-1-(4-hydroxyphenyl)-2-propen-1-one | (E)-3-(5-chloro-3-methyl-1-phenyl-pyrazol-4-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one | (E)-3-(5-chloro-3-methyl-1-phenylpyrazol-4-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one | MLS000393631 | SMR000247780 | cid_5862282
Type:
Small organic molecule
Emp. Form.:
C19H15ClN2O2
Mol. Mass.:
338.788
SMILES:
Cc1nn(c(Cl)c1\C=C\C(=O)c1ccc(O)cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: