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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90256
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90256
Synonyms:
2-[(2,5-dichlorophenyl)thio]acetic acid [2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl] ester | 2-[(2,5-dichlorophenyl)thio]acetic acid [2-keto-2-(piperonylamino)ethyl] ester | MLS000391021 | SMR000260058 | [2-(1,3-benzodioxol-5-ylmethylamino)-2-oxidanylidene-ethyl] 2-[2,5-bis(chloranyl)phenyl]sulfanylethanoate | [2-(1,3-benzodioxol-5-ylmethylamino)-2-oxoethyl] 2-(2,5-dichlorophenyl)sulfanylacetate | cid_4102642
Type:
Small organic molecule
Emp. Form.:
C18H15Cl2NO5S
Mol. Mass.:
428.286
SMILES:
Clc1ccc(Cl)c(SCC(=O)OCC(=O)NCc2ccc3OCOc3c2)c1
Structure:
Search PDB for entries with ligand similarity: