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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90258
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90258
Synonyms:
MLS000418444 | SMR000264965 | [4-[(E)-2-(2-methoxyethoxycarbonyl)-3-oxidanylidene-but-1-enyl]phenyl] benzoate | [4-[(E)-2-(2-methoxyethoxycarbonyl)-3-oxobut-1-enyl]phenyl] benzoate | benzoic acid [4-[(E)-2-[2-methoxyethoxy(oxo)methyl]-3-oxobut-1-enyl]phenyl] ester | benzoic acid [4-[(E)-3-keto-2-(2-methoxyethoxycarbonyl)but-1-enyl]phenyl] ester | cid_2320001
Type:
Small organic molecule
Emp. Form.:
C21H20O6
Mol. Mass.:
368.3799
SMILES:
COCCOC(=O)C(=Cc1ccc(OC(=O)c2ccccc2)cc1)C(C)=O |w:8.8|
Structure:
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