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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM46982
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
4960±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM46982
Synonyms:
MLS000830750 | N-[3-(5-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-2H-1,2,3,4-tetraazol-2-yl)phenyl]acetamide | N-[3-[5-[2-(4-methoxyphenyl)-2-oxidanylidene-ethyl]sulfanyl-1,2,3,4-tetrazol-2-yl]phenyl]ethanamide | N-[3-[5-[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyltetrazol-2-yl]phenyl]acetamide | N-[3-[5-[[2-(4-methoxyphenyl)-2-oxoethyl]thio]-2-tetrazolyl]phenyl]acetamide | N-[3-[5-[[2-keto-2-(4-methoxyphenyl)ethyl]thio]tetrazol-2-yl]phenyl]acetamide | SMR000458171 | cid_2810542
Type:
Small organic molecule
Emp. Form.:
C18H17N5O3S
Mol. Mass.:
383.424
SMILES:
COc1ccc(cc1)C(=O)CSc1nnn(n1)-c1cccc(NC(C)=O)c1
Structure:
Search PDB for entries with ligand similarity: