Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80510
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2
Temperature
298.15±n/a K
IC50
26600±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80510
Synonyms:
2-(3-methyl-1-pyridin-1-iumyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]acetamide;chloride | 2-(3-methylpyridin-1-ium-1-yl)-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]acetamide;chloride | 2-(3-methylpyridin-1-ium-1-yl)-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]ethanamide;chloride | 2-(3-methylpyridin-1-ium-1-yl)-N-[2-morpholino-5-(trifluoromethyl)phenyl]acetamide;chloride | MLS000771355 | SMR000344445 | cid_16196233
Type:
Small organic molecule
Emp. Form.:
C19H21F3N3O2
Mol. Mass.:
380.3836
SMILES:
Cc1ccc[n+](CC(=O)Nc2cc(ccc2N2CCOCC2)C(F)(F)F)c1
Structure:
