Reaction Details Report a problem with these data
Target
dCTP deaminase
Ligand
BDBM50173546
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
Ki
1000000±0.0 nM
Citation
 Musso-Buendía, JA; Vidal, AE; Kasinthan, G; Nguyen, C; Carrero-Lérida, J; Ruiz-Pérez, LM; Wilson, K; Johansson, NG; Gilbert, IH; González-Pacanowska, D Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. J Enzyme Inhib Med Chem 24:111-6 (2009) [PubMed]  Article 
Target
Name:
dCTP deaminase
Synonyms:
DCD_CAMJE | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | dcd
Type:
Protein
Mol. Mass.:
20698.65
Organism:
Campylobacter jejuni
Description:
n/a
Residue:
186
Sequence:
MGLKADNWIRKMALEHKMIEPFCEANIGKGVVSYGLSSYGYDIRVGREFKIFTNVNSTVVDPKNFVEENVVDFEGDVCIVPANSFALARTIEYFKMPDNVLAICLGKSTYARCGIIVNVTPFEPGFEGHITIEISNTTPLPAKIYANEGIAQVLFLQGDEKCDTTYKDKKGKYQAQTGITLPRILK
  
Inhibitor
Name:
BDBM50173546
Synonyms:
1-(5-Trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione | CHEMBL369937 | dUTPase inhibitor, 2
Type:
Small organic molecule
Emp. Form.:
C28H24N2O4
Mol. Mass.:
452.5012
SMILES:
O=c1ccn(C2OC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)C=C2)c(=O)[nH]1 |c:32|
Structure:
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