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Target
Tryptophanase
Ligand
BDBM91686
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±0
Temperature
298.15±0 K
Ki
48000000±3000000 nM
Citation
 Scherzer, R; Gdalevsky, GY; Goldgur, Y; Cohen-Luria, R; Bittner, S; Parola, AH New tryptophanase inhibitors: towards prevention of bacterial biofilm formation. J Enzyme Inhib Med Chem 24:350-5 (2009) [PubMed]  Article 
Target
Name:
Tryptophanase
Synonyms:
L-tryptophan indole-lyase | TNAA_ECOLI | ind | tnaA
Type:
Enzyme
Mol. Mass.:
52770.85
Organism:
Escherichia coli
Description:
P0A853
Residue:
471
Sequence:
MENFKHLPEPFRIRVIEPVKRTTRAYREEAIIKSGMNPFLLDSEDVFIDLLTDSGTGAVTQSMQAAMMRGDEAYSGSRSYYALAESVKNIFGYQYTIPTHQGRGAEQIYIPVLIKKREQEKGLDRSKMVAFSNYFFDTTQGHSQINGCTVRNVYIKEAFDTGVRYDFKGNFDLEGLERGIEEVGPNNVPYIVATITSNSAGGQPVSLANLKAMYSIAKKYDIPVVMDSARFAENAYFIKQREAEYKDWTIEQITRETYKYADMLAMSAKKDAMVPMGGLLCMKDDSFFDVYTECRTLCVVQEGFPTYGGLEGGAMERLAVGLYDGMNLDWLAYRIAQVQYLVDGLEEIGVVCQQAGGHAAFVDAGKLLPHIPADQFPAQALACELYKVAGIRAVEIGSFLLGRDPKTGKQLPCPAELLRLTIPRATYTQTHMDFIIEAFKHVKENAANIKGLTFTYEPKVLRHFTAKLKEV
  
Inhibitor
Name:
BDBM91686
Synonyms:
N-acetyl tryptophan
Type:
Small organic molecule
Emp. Form.:
C13H14N2O3
Mol. Mass.:
246.2619
SMILES:
CC(=O)NC(Cc1c[nH]c2ccccc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: