Reaction Details Report a problem with these data
Target
Tryptophanase
Ligand
BDBM91688
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±0
Temperature
298.15±0 K
Ki
101000000±2000000 nM
Citation
 Scherzer, R; Gdalevsky, GY; Goldgur, Y; Cohen-Luria, R; Bittner, S; Parola, AH New tryptophanase inhibitors: towards prevention of bacterial biofilm formation. J Enzyme Inhib Med Chem 24:350-5 (2009) [PubMed]  Article 
Target
Name:
Tryptophanase
Synonyms:
L-tryptophan indole-lyase | TNAA_ECOLI | ind | tnaA
Type:
Enzyme
Mol. Mass.:
52770.85
Organism:
Escherichia coli
Description:
P0A853
Residue:
471
Sequence:
MENFKHLPEPFRIRVIEPVKRTTRAYREEAIIKSGMNPFLLDSEDVFIDLLTDSGTGAVTQSMQAAMMRGDEAYSGSRSYYALAESVKNIFGYQYTIPTHQGRGAEQIYIPVLIKKREQEKGLDRSKMVAFSNYFFDTTQGHSQINGCTVRNVYIKEAFDTGVRYDFKGNFDLEGLERGIEEVGPNNVPYIVATITSNSAGGQPVSLANLKAMYSIAKKYDIPVVMDSARFAENAYFIKQREAEYKDWTIEQITRETYKYADMLAMSAKKDAMVPMGGLLCMKDDSFFDVYTECRTLCVVQEGFPTYGGLEGGAMERLAVGLYDGMNLDWLAYRIAQVQYLVDGLEEIGVVCQQAGGHAAFVDAGKLLPHIPADQFPAQALACELYKVAGIRAVEIGSFLLGRDPKTGKQLPCPAELLRLTIPRATYTQTHMDFIIEAFKHVKENAANIKGLTFTYEPKVLRHFTAKLKEV
  
Inhibitor
Name:
BDBM91688
Synonyms:
S-phenylbenzoquinone tryptophan
Type:
Small organic molecule
Emp. Form.:
C23H18N2O4S
Mol. Mass.:
418.465
SMILES:
OC(=O)C(Cc1c[nH]c2ccccc12)=Nc1cc(O)c(Sc2ccccc2)cc1O |w:14.16|
Structure:
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