Target
Protein RecA
Ligand
BDBM92386
Substrate
n/a
Meas. Tech.
Fluorescent Reporter Assay
IC50
2.5e+3±n/a nM
Citation
 Zhang, LZheng, YCallahan, BBelfort, MLiu, Y Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria. J Biol Chem 286:1277-82 (2011) [PubMed]  Article 
Target
Name:
Protein RecA
Synonyms:
RECA_ECOLI | lexB | recA | recH | rnmB | tif | umuB | zab
Type:
Protein
Mol. Mass.:
37964.88
Organism:
Escherichia coli
Description:
C6EJT2
Residue:
353
Sequence:
MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF
  
Inhibitor
Name:
BDBM92386
Synonyms:
Cisplatin, 1 | trans-DDP, 8
Type:
Small molecule
Emp. Form.:
Cl2H6N2Pt
Mol. Mass.:
300.05
SMILES:
[NH3+][Pt]([NH3+])(Cl)Cl
Structure:
Search PDB for entries with ligand similarity: