Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM34233
Substrate
BDBM92519
Meas. Tech.
Tautomerase Enzyme Assay
pH
6.5±0
Ki
5.7e+2±n/a nM
IC50
2.40e+3±n/a nM
Citation
 Ouertatani-Sakouhi, H; El-Turk, F; Fauvet, B; Cho, MK; Pinar Karpinar, D; Le Roy, D; Dewor, M; Roger, T; Bernhagen, J; Calandra, T; Zweckstetter, M; Lashuel, HA Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. J Biol Chem 285:26581-98 (2010) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM34233
Synonyms:
2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebselen) | 2-phenyl-1,2-benzisoselazol-3(2H)-one | 2-phenyl-1,2-benzoselenazol-3-one | 2-phenylbenzo[d][1,2]selenazol-3(2H)-one | CHEMBL51085 | EBSELEN | Ebselen (C5) | MLS000028488 | SMR000058445 | cid_3194 | med.21724, Compound 153
Type:
Small organic molecule
Emp. Form.:
C13H9NOSe
Mol. Mass.:
274.18
SMILES:
O=c1n([se]c2ccccc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM92519
Synonyms:
D-Dopachrome
Type:
Substrate
Emp. Form.:
C9H7NO4
Mol. Mass.:
193.1562
SMILES:
OC(=O)[C@H]1CC2=CC(=O)C(=O)CC2=N1 |c:13,t:5|
Structure:
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