Reaction Details Report a problem with these data
Target
Poly(A)-specific ribonuclease PARN
Ligand
BDBM92909
Substrate
n/a
Meas. Tech.
PARN Activity Assay
Ki
5.10e+5± 5.2e+4 nM
Citation
 Balatsos, NA; Vlachakis, D; Maragozidis, P; Manta, S; Anastasakis, D; Kyritsis, A; Vlassi, M; Komiotis, D; Stathopoulos, C Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides. Biochemistry 48:6044-51 (2009) [PubMed]  Article 
Target
Name:
Poly(A)-specific ribonuclease PARN
Synonyms:
DAN | PARN | PARN_HUMAN | Poly(A)-specific ribonuclease (PARN) | Polyadenylate-specific ribonuclease
Type:
Enzyme
Mol. Mass.:
73446.57
Organism:
Homo sapiens (Human)
Description:
O95453
Residue:
639
Sequence:
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW
  
Inhibitor
Name:
BDBM92909
Synonyms:
Nucleoside, A2
Type:
Small molecule
Emp. Form.:
C17H16FN5O5
Mol. Mass.:
389.3378
SMILES:
OC1OC(C(O)C(F)C1O)n1cnc2c(NC(=O)c3ccccc3)ncnc12
Structure:
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