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Target
Peptidyl-prolyl cis-trans isomerase D
Ligand
BDBM92912
Substrate
n/a
Meas. Tech.
PPIase Assay
pH
7.8±n/a
Temperature
278.15±n/a K
Ki
2.42e+3± 7.6e+2 nM
Comments
extracted
Citation
 Daum, S; Schumann, M; Mathea, S; Aumüller, T; Balsley, MA; Constant, SL; de Lacroix, BF; Kruska, F; Braun, M; Schiene-Fischer, C Isoform-specific inhibition of cyclophilins. Biochemistry 48:6268-77 (2009) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase D
Synonyms:
40 kDa peptidyl-prolyl cis-trans isomerase | CYP-40 | CYP40 | CYPD | Cyclophilin D (CypD) | Cyclophilin-40 | Cyclophilin-related protein | PPID | PPID_HUMAN | PPIase D | Peptidyl-prolyl cis-trans isomerase D | Rotamase D
Type:
Protein
Mol. Mass.:
40766.62
Organism:
Homo sapiens (Human)
Description:
Q08752
Residue:
370
Sequence:
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
  
Inhibitor
Name:
BDBM92912
Synonyms:
Aryl 1-indanylketone, 1
Type:
Small molecule
Emp. Form.:
C22H15FN2O7
Mol. Mass.:
438.3621
SMILES:
Oc1c(cc(cc1N(=O)=O)-c1cc(F)cc(c1O)N(=O)=O)C(=O)C1CCc2ccccc12
Structure:
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