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Target
Thiamine-binding periplasmic protein
Ligand
BDBM50373877
Substrate
n/a
Meas. Tech.
Titration Assay
Kd
3.8±0.3 nM
Citation
 Soriano, EV; Rajashankar, KR; Hanes, JW; Bale, S; Begley, TP; Ealick, SE Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry 47:1346-57 (2008) [PubMed]  Article 
Target
Name:
Thiamine-binding periplasmic protein
Synonyms:
THIB_ECOLI | tbpA | thiB | yabL
Type:
Protein
Mol. Mass.:
36163.97
Organism:
Escherichia coli (strain K12)
Description:
P31550
Residue:
327
Sequence:
MLKKCLPLLLLCTAPVFAKPVLTVYTYDSFAADWGPGPVVKKAFEADCNCELKLVALEDGVSLLNRLRMEGKNSKADVVLGLDNNLLDAASKTGLFAKSGVAADAVNVPGGWNNDTFVPFDYGYFAFVYDKNKLKNPPQSLKELVESDQNWRVIYQDPRTSTPGLGLLLWMQKVYGDDAPQAWQKLAKKTVTVTKGWSEAYGLFLKGESDLVLSYTTSPAYHILEEKKDNYAAANFSEGHYLQVEVAARTAASKQPELAQKFLQFMVSPAFQNAIPTGNWMYPVANVTLPAGFEKLTKPATTLEFTPAEVAAQRQAWISEWQRAVSR
  
Inhibitor
Name:
BDBM50373877
Synonyms:
Betaxin | CA inhibitor, 3 | THIAMINE (VIT B1) | ThOH | Thiamine | Vitamin B 1
Type:
Small organic molecule
Emp. Form.:
C12H17N4OS
Mol. Mass.:
265.354
SMILES:
Cc1c(CCO)sc[n+]1Cc1cnc(C)nc1N
Structure:
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