Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50374600
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
311±n/a nM
Citation
 Yous, S; Wallez, V; Belloir, M; Caignard, DH; McCurdy, CR; Poupaert, JH Novel 2(3H)-benzothiazolones as highly potent and selective sigma-1 receptor ligands Medicinal Chemistry Research 14:158-168 (2005)    Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50374600
Synonyms:
CHEMBL272899
Type:
Small organic molecule
Emp. Form.:
C18H26N2OS
Mol. Mass.:
318.477
SMILES:
CCCc1ccc2n(CCN3CCCCCC3)c(=O)sc2c1
Structure:
Search PDB for entries with ligand similarity: