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Target
Sentrin-specific protease 8
Ligand
BDBM93576
Substrate
n/a
IC50
3660±326 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93576
Synonyms:
MLS000677451 | N-(6-methoxy-4H-indeno[1,2-d][1,3]thiazol-2-yl)pyridine-3-carboxamide | N-(6-methoxy-4H-indeno[1,2-d]thiazol-2-yl)-3-pyridinecarboxamide | N-(6-methoxy-4H-indeno[1,2-d]thiazol-2-yl)nicotinamide | SMR000286189 | cid_769125
Type:
Small organic molecule
Emp. Form.:
C17H13N3O2S
Mol. Mass.:
323.369
SMILES:
COc1ccc-2c(Cc3sc(NC(=O)c4cccnc4)nc-23)c1
Structure:
Search PDB for entries with ligand similarity: