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Target
Caspase-3
Ligand
BDBM34906
Substrate
n/a
IC50
93300±7410 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM34906
Synonyms:
5-amino-3-(2-methylphenyl)-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid ethyl ester | 5-amino-4-keto-3-(o-tolyl)thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester | MLS000707247 | SMR000288712 | cid_892976 | ethyl 5-amino-3-(2-methylphenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate | ethyl 5-azanyl-3-(2-methylphenyl)-4-oxidanylidene-thieno[3,4-d]pyridazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H15N3O3S
Mol. Mass.:
329.374
SMILES:
CCOC(=O)c1nn(-c2ccccc2C)c(=O)c2c(N)scc12
Structure:
Search PDB for entries with ligand similarity: