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Target
Caspase-3
Ligand
BDBM93576
Substrate
n/a
IC50
29200±1490 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM93576
Synonyms:
MLS000677451 | N-(6-methoxy-4H-indeno[1,2-d][1,3]thiazol-2-yl)pyridine-3-carboxamide | N-(6-methoxy-4H-indeno[1,2-d]thiazol-2-yl)-3-pyridinecarboxamide | N-(6-methoxy-4H-indeno[1,2-d]thiazol-2-yl)nicotinamide | SMR000286189 | cid_769125
Type:
Small organic molecule
Emp. Form.:
C17H13N3O2S
Mol. Mass.:
323.369
SMILES:
COc1ccc-2c(Cc3sc(NC(=O)c4cccnc4)nc-23)c1
Structure:
Search PDB for entries with ligand similarity: