Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM77990
Substrate
n/a
IC50
10500±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM77990
Synonyms:
4-(2-furanyl)-3-propan-2-yl-N-(3-pyridinyl)-2-thiazolimine | 4-(furan-2-yl)-3-propan-2-yl-N-pyridin-3-yl-1,3-thiazol-2-imine | MLS000056411 | SMR000067324 | [4-(2-furyl)-3-isopropyl-4-thiazolin-2-ylidene]-(3-pyridyl)amine | cid_2998728
Type:
Small organic molecule
Emp. Form.:
C15H15N3OS
Mol. Mass.:
285.364
SMILES:
CC(C)n1c(cs\c1=N/c1cccnc1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: