Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM89250
Substrate
n/a
IC50
2680±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89250
Synonyms:
(4-Benzothiazol-2-yl-piperazin-1-yl)-(4-benzyl-4H-thieno[3,2-b]pyrrol-5-yl)-methanone | MLS000529385 | SMR000121860 | [4-(1,3-benzothiazol-2-yl)-1-piperazinyl]-[4-(phenylmethyl)-5-thieno[3,2-b]pyrrolyl]methanone | [4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-(4-benzylthieno[3,2-b]pyrrol-5-yl)methanone | [4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-[4-(phenylmethyl)thieno[3,2-b]pyrrol-5-yl]methanone | [4-(1,3-benzothiazol-2-yl)piperazino]-(4-benzylthieno[3,2-b]pyrrol-5-yl)methanone | cid_3225147
Type:
Small organic molecule
Emp. Form.:
C25H22N4OS2
Mol. Mass.:
458.598
SMILES:
O=C(N1CCN(CC1)c1nc2ccccc2s1)c1cc2sccc2n1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: