Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM43528
Substrate
n/a
IC50
8300±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM43528
Synonyms:
(4-chlorophenyl)-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]methanone | (4-chlorophenyl)-[4-(7-chloro-4-quinolyl)piperazino]methanone | (4-chlorophenyl)-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]methanone | 7-chloro-4-[4-(4-chlorobenzoyl)-1-piperazinyl]quinoline | MLS000676065 | SMR000296226 | [4-(7-chloranylquinolin-4-yl)piperazin-1-yl]-(4-chlorophenyl)methanone | cid_1251584
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2N3O
Mol. Mass.:
386.274
SMILES:
Clc1ccc(cc1)C(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: