Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM89413
Substrate
n/a
IC50
1300±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89413
Synonyms:
5-(5-isoquinolinyloxymethyl)-N-methyl-N-(2-thiazolylmethyl)-3-isoxazolecarboxamide | 5-(5-isoquinolyloxymethyl)-N-methyl-N-(thiazol-2-ylmethyl)isoxazole-3-carboxamide | 5-(isoquinolin-5-yloxymethyl)-N-methyl-N-(1,3-thiazol-2-ylmethyl)-1,2-oxazole-3-carboxamide | MLS001101358 | SMR000654990 | cid_24817446
Type:
Small organic molecule
Emp. Form.:
C19H16N4O3S
Mol. Mass.:
380.42
SMILES:
CN(Cc1nccs1)C(=O)c1cc(COc2cccc3cnccc23)on1
Structure:
Search PDB for entries with ligand similarity: