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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89733
Substrate
n/a
IC50
3480±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89733
Synonyms:
1-(2,5-dimethoxyphenyl)sulfonyl-2-methyl-2,3-dihydroindole | 1-(2,5-dimethoxyphenyl)sulfonyl-2-methyl-indoline | 1-[(2,5-dimethoxyphenyl)sulfonyl]-2-methylindoline | MLS000096610 | SMR000073745 | cid_2943266
Type:
Small organic molecule
Emp. Form.:
C17H19NO4S
Mol. Mass.:
333.402
SMILES:
COc1ccc(OC)c(c1)S(=O)(=O)N1C(C)Cc2ccccc12
Structure:
Search PDB for entries with ligand similarity: