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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90403
Substrate
n/a
IC50
2650±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90403
Synonyms:
6-bromanyl-N-[1-[(2-methylphenyl)methyl]pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-2-carboxamide | 6-bromo-N-[1-(2-methylbenzyl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-2-carboxamide | 6-bromo-N-[1-(2-methylbenzyl)pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-2-carboxamide | 6-bromo-N-[1-[(2-methylphenyl)methyl]-3-pyrazolyl]-2-pyrazolo[1,5-a]pyrimidinecarboxamide | 6-bromo-N-[1-[(2-methylphenyl)methyl]pyrazol-3-yl]pyrazolo[1,5-a]pyrimidine-2-carboxamide | MLS000679687 | SMR000296931 | cid_1259129
Type:
Small organic molecule
Emp. Form.:
C18H15BrN6O
Mol. Mass.:
411.255
SMILES:
Cc1ccccc1Cn1ccc(NC(=O)c2cc3ncc(Br)cn3n2)n1
Structure:
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