Reaction Details
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Corticotropin-releasing factor-binding protein
Ligand
BDBM90084
Substrate
n/a
IC50
5070±n/a nM
Citation
PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
Inhibitor
Name:
BDBM90084
Synonyms:
2-Acetylamino-N-(3'-nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-3-p-tolyl-propionamide | 2-acetamido-3-(4-methylphenyl)-N-[1-(3-nitro-2-pyridinyl)-4-piperidinyl]propanamide | 2-acetamido-3-(4-methylphenyl)-N-[1-(3-nitropyridin-2-yl)piperidin-4-yl]propanamide | 2-acetamido-N-[1-(3-nitro-2-pyridyl)-4-piperidyl]-3-(p-tolyl)propionamide | MLS000559312 | SMR000173735 | cid_3232421
Type:
Small organic molecule
Emp. Form.:
C22H27N5O4
Mol. Mass.:
425.4809
SMILES:
CC(=O)NC(Cc1ccc(C)cc1)C(=O)NC1CCN(CC1)c1ncccc1[N+]([O-])=O
Structure:
